https://imcjms.com/public Ibrahim Medical College Journal of Medical Science https://imcjms.com/public/registration/journal_full_text/70 Tue, 02 Aug 2016 12:07:35 +0000 Polycystic ovary syndrome (PCOS) is one of the common disorders in women at child bearing age. The purpose of the present study was to investigate the lipid profile in patients with polycystic ovary syndrome. Ibrahim Med. Coll. J. 2014; 8(2): 47-49 Address for Correspondence: Dr. Rona Laila, Assistant Professor, BIRDEM General Hospital. 1/1 Ibrahim Sarani, Segunbagicha, Dhaka-1000, Bangladesh. Mobile: +8801711985438, Email: ronalaila7776@gmail.com   One of the most common disorders in women at child bearing age is polycystic ovary syndrome (PCOS), which is a complex disorder affecting not only the normal development of eggs in the ovaries but also other metabolic pathways.1-3 PCOS is a common endocrine disorder affecting 5-10% women of reproductive age.4,5 It is associated with diabetes and cardiovascular disease. In view of the above, the present study was undertaken to evaluate the lipid parameters in women with PCOS.        Study population Anthropometry and laboratory methods Oral glucose tolerance test (OGTT) was performed in all subjects following the WHO criteria (1999). The selected subjects were requested to fast overnight (8-12 hours). In the following morning, fasting blood samples (10 cc) was collected in an EDTA containing tube. After two hrs of glucose load (75 gm) another 5 ml blood was drawn in another tube. Serum lipids were determined from fasting sample.   The detail anthropometric characteristics of the study population are shown in Table 1. The mean BMI±SD of the 103 participants was 25.84±5.54 kg/m2. Out of 103 study women 50 (48.5%) had family history of diabetes. Among 103 women with PCOS, 30 (29.1%) showed impaired glucose tolerance (OGTT value: 7.8-11.0 mmol/L), 5 (4.9%) were T2DM (fasting blood sugar >7.0, OGTT value >11.1mmol/L) and 68 (66%) showed normal glucose tolerance (OGTT value <7.8 mmol/L). Table-1: Anthropometric and other characteristics of the study population (n=103)  Detailed anthropometry, laboratory and other clinical characteristics of women with PCOS having NGT, IGT and T2DM are recorded in Table 2. Mean age of NGT, IGT, and T2DM was 23.68±4.57, 25.03±6.09 and 30.48±2.88 years respectively. The BMI of women having NGT, IGT and T2DM ranged from 24.86 kg/m2 to 32.7 kg/m2.In NGT group 16.2% had BMI>30 kg/m2 where as 23.3% of IGT and 40% of T2DM had BMI>30 kg/m2. The mean cholesterol levels in NGT, IGT and T2DM groups ranged from 182 mg/dl to 236 mg/dl. Details of other lipid parameters are shown in the Table 2. Table-2: Anthropometric, laboratory and other characteristics of women with PCOS having NGT, IGT and T2DM  Discussion Dyslipidemia is common in PCOS compared to weight matched controls with higher triglyceride and lower high-density lipoprotein cholesterol.9,11 The dyslipidaemia occurs independent of BMI.14 The causes of dyslipidaemia in PCOS are again multi-factorial. Insulin resistance appears to have an important role mediated by simulation of lipolysis and altered expression of lipoprotein lipase and hepatic lipase.15 It is thought that approximately 70% of the patients with PCOS have disturbances in serum lipid levels.16 A study on Bangladeshi women with PCOS reported increased levels of triglyceride, LDL and total cholesterol.17 In our study, the lipid profiles of women with PCOS was generally higher than normal healthy women.   1.    Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES and Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004; 89: 2745-49. 3.    Taylor, A.E. Understanding the underlying metabolic abnormalities of polycystic ovary syndrome. Am J Obstet Gynecol 1998; 179: S94-S100. 5.    Diamanti-Kandarakis E, Kouli CR, Bergiele AT, et al. 6.    Wild RA, Alaupovic P, Parker IJ. Lipid and  apolipoprotein abnormalities in hirsute women. Am J Obstet Gynecol 1992; 166: 1191-97. 8.    DeFronzo RA, Hendler R, Simonson. Insulin resistance; a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerosis. Neth J Med 1997; 50: 191-97. 10.  Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF et al. Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003; 88(6): 2562-68. 12.  Moran LJ, Misso M, Wild RA, Norman R. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: A systematic review and  meta-analysis. Human Reproduction Update 2010; 16: 347-63. 14.  Wild RA, Bartholomew MJ. The influence of body weight on lipoprotein lipids in patients with polycystic ovary syndrome. Am J Obstet Gynecol 1988; 159: 423-27. 16.  Gateva A, Kamenov Z. Cardiovascular risk factors in Bulgarian patients with polycystic  ovary syndrome and/or obesity. Obstet Gynecol Int 2012; doi: 10.1155/2012/306347. 2026 Ibrahim Medical College. All rights reserved.