https://imcjms.com Ibrahim Medical College Journal of Medical Science https://imcjms.com/registration/journal_full_text/248 Mon, 10 Jul 2017 09:11:05 +0000 Resistance to thyrotropin or thyroid stimulating hormone (RTSH) can be defined as decreased responsiveness to thyroid stimulating hormone (TSH) characterized by high TSH with normal but occasionally low T4 and T3 usually in absence of goiter or ectopic thyroid. It can be diagnosed when TSH is >30 mIU/L but free T4 (FT4) is within normal limit. Patient usually presents in euthyroid state with abnormally high TSH but may also present with mild to overt hypothyroidism. The precise prevalence is not known, but 20-30% infants may show transient mild RTSH. In adults it is rare. Ibrahim Med. Coll. J. 2014; 8(1): 32-33 Keyword:  Resistance syndrome, TSH, FT4 Address for Correspondence: Dr. S.M. Ashrafuzzaman, Associate Proessor, Department of Endocrinology, BIRDEM, 122 Kazi Nazrul Islam Avenue, Shahbag, Dhaka, Bangladesh. E-mail: ashraf_zaman1961@yahoo.com     Resistance to thyroid stimulating hormone (TSH) is a syndrome characterized by a high serum TSH level due to decreased sensitivity of thyroid cells to TSH. It can be diagnosed when TSH level is >30 mIU/L. However thyroid hormone concentration may vary, normal to high depending upon the resistance.1,2 Patients may present in euthyroid state with or without goiter. Some may present with mild to severe hypothyroidism. Affected individuals usually have normal or hypoplastic thyroid glands, high serum TSH concentrations, and normal or low serum T4 and T3 concentrations. In case of hypothyroidism of RTSH, even after treatment with thyroxin, FT4 remains within normal range but TSH remains very high.   A 19 years old girl came to the deparment of Endocrinology of BIRDEM General Hospital with the complains of swelling in front of the neck (Thyroid) for last 6 months. She was born by normal vaginal delivery and her parents were unrelated. There was no history of developmental delay or growth retardation. She had no signs or symptoms of thyroid dysfunction (hypo or hyper) except thyroid enlargement (WHO Grade 2a). She had menarche at 11 years of age and her menstrual cycle was regular. She was the youngest among 3 children of her parents. There was  no history of thyroid disease or any autoimmune disease in her family. She was from a low income family and her intelligence quotient (IQ) was normal. Investigations showed Free T4 (FT4) 14.6 pmol/L (Normal RR 9.14-23.81) and TSH >100 mIU/ml (Normal RR 0.47-5.01). Anti-thyroid antibody was negative. Ultrasonogram of thyroid gland revealed mild enlargement of both lobes (right Lobe 3.5 cm and left lobe 3.2 cm at its long axis). Thyroid scan (99Tc) showed diffuse mild enlargement of both lobes. As patient was completely euthyroid with only mild diffuse goiter and normal FT4 but had very high TSH level, the diagnosis was thyroid stimulating hormone resistance syndrome (RTSH). No thyroxin was given and the patient was kept in follow up.   TSH resistance syndromes (RTSH) can be broadly defined as reduced or absent end-organ responsiveness to thyrotropin or TSH. The other forms of disorders of thyroid may be reduced sensitivity to thyroid hormone which is a process that impairs the effectiveness of thyroid hormone and ersistent elevation of serum levels of T4 and T3 with “inappropriately” nonsuppressed TSH.1 Affected individual with RTSH has high serum TSH concentrations, and normal or low serum T4 and T3 concentrations. They are often identified at birth through neonatal screening for congenital hypothyroidism. When FT4 is within normal limit but TSH is >30 mIU/L, it indicates TSH resistance. The most important differential diagnosis is TSH secreting tumor of the pituitary, which presents with thyrotoxicosis, high TSH with high T4 and T3. Though the precise prevalence is not known, but 20-30% infants may show mild RTSH which is transient. In adults it is rare. RTSH is inherited in either autosomal recessive or dominant manner.1,3 Three genetic causes of RTSH have been so far identified. They involve two distinct genes and linkage to a gene locus. The hormone resistance may be due to the following mechanisms: Impaired biologic activity of the hormone, impaired function of hormone receptor, quantitative reduction in receptor without receptor gene defect and post receptor abnormalities.3-5 In our case, the patient had fully compensated RTSH and  need no thyroxin. Such cases should be monitored every 6-12 months for thyroid functions. In our knowledge, previously no RTSH case was reported from Bangladesh. Reference 2.    Refetoff S. Resistance to thyrotropin. J Endocrinol Invest 2003; 26: 770-9. 4.    Ahlbom BD, Yaqoob M, Larsson A, et al. Genetic and linkage analysis of familial congenital hypothyroidism: exclusion of linkage to the TSH receptor gene. Hum Genet 1997; 99: 186. 2026 Ibrahim Medical College. All rights reserved.