Department of Pharmacology, Dhaka Medical College, Dhaka, Bangladesh
Background and objectives:
Aegle marmelos (Bael), a medicinal
plant, has been widely used indigenously to treat many diseases in Bangladesh
and other countries. The present study was carried out to evaluate the efficacy
of A. marmelos leaf to prevent ethanol induced gastric
ulcer in a rat model.
Methods: Thirty two Wister albino rats of either sex, weighing between 100-150g,
were fed 200
mg/kg or 400 mg/kg aqueous extract of A. marmelos
leaves one hour prior to oral administration of 90% ethanol (1 ml/200 gm
body weight) to induce gastric ulcer. The animals were sacrificed after one
hour and ulcer scores and index were determined. The protective efficacy of A. marmelos aqueous extract was
expressed as percentage protection of ulcer.
Aqueous extract exhibited significant (p<0.05) dose dependent protection
against gastric ulcer formation by ethanol in rat stomach. Percentage
protection of ulcer with 200 mg/kg and 400 mg/kg of aqueous extract of A. marmelos leave were 19.3% and 37.2% respectively
compared to standard anti-peptic ulcer drug omeprazole (50.4%).
Conclusion: Thus, crude extracts
of A. marmelos leave have been shown
to have potential ability to prevent experimentally induced peptic ulcer
formation in animal model.
IMC J Med Sci 2018; 12(1): 11-14
for Correspondence: Dr. Sharmin Rahman, Assistant Professor, Department of
Pharmacology, Ibrahim Medical College, 122 Kazi Nazrul Islam Avenue, Shahbagh,
Dhaka-1000, Bangladesh. Email: firstname.lastname@example.org