Department of Nephrology, Ibrahim Medical College & BIRDEM General Hospital, Dhaka, Bangladesh
Department of Internal Medicine, Ibrahim Medical College & BIRDEM General Hospital, Dhaka, Bangladesh
Department of Medicine, Delta Medical College and Hospital, Dhaka, Bangladesh
Department of Cardiology, National Institute of Cardio-Vascular Diseases (NICVD), Dhaka, Bangladesh
and objectives: Diabetes mellitus is
one of the most common causes of chronic kidney disease (CKD). The prevalence
of CKD in type 2 diabetes mellitus (T2DM) in Bangladesh is not well described.
The present study aimed to find out the prevalence of CKD stages 3-5 and its
risk factors among selected Bangladeshi T2DM patients.
This cross-sectional study was conducted in BIRDEM (Bangladesh Institute of
Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) General
Hospital, Dhaka, Bangladesh from July to December 2015. Diagnosed adult T2DM
patients were consecutively and purposively included in this study. Pregnant women,
patients with diagnosed kidney disease due to non-diabetic etiology, acute
kidney injury (AKI), AKI on CKD and patients on renal replacement therapy were
excluded. Age, gender, body mass index (BMI) and laboratory parameters were
recorded systematically in a predesigned data sheet. Diagnosis of CKD and its stages
were determined according to Kidney Disease: Improving Global Outcomes (KDIGO)
Clinical Practice Guidelines 2012 and estimated glomerular filtration rate
(eGFR). Estimated GFR was calculated by using Modification of Diet in Renal
Disease (MDRD), Cockcroft-Gault (CG) and Chronic Kidney Disease Epidemiology (CKD-EPI)
creatinine based formula.
A total of 400 patients with T2DM of various durations were enrolled in the
study. Out of 400 patients, 254 (63.5%), 259 (64.75%) and 218 (54.5%) cases had
CKD stages 3-5 according to MDRD, C-G and CKD-EPI equations respectively. CKD
was significantly more common in
females (p<0.001) and in cases with long duration of diabetes (≥5 years; p=0.007). CKD stages
3-5 were significantly associated with hypertension (χ2=5.2125, p =0.02) and good control of diabetes (HbA1c <7%) as evidenced by higher proportion of
CKD in them (73.3%) compared to those with poor glycemic control (52.1%).
More than half of T2DM patients had CKD stages 3-5. Female gender, duration of
diabetes and hypertension were significant risk factors and should be emphasized
for the prevention of CKD in T2DM. Glycemic control may not reduce CKD in
IMC J Med Sci 2017; 11(1): 19-24