Department of Immunology,Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorder (BIRDEM),Shahbag, Dhaka
Background and objectives: It is well known that children with Down syndrome (DS)
suffer from frequent infections. There is an association of certain IgG
subclass abnormalities with the predisposition to recurrent infection of the respiratory
tract. Therefore, the study was conducted to determine the immunoglobulin G1 and
G2 (IgG1, IgG2) profile in children with DS.
Material and methods: Forty children between the ages of 6 months to 12 years
with DS (47 XX/XY, +21) attending the Department of Immunology, BIRDEM were
enrolled in the study. Age and sex matched 30 healthy normal children with 46 XX/XY
were included as control. Enrolled DS and healthy children were divided into
two age groups namely 6 months to 6 years and 7 years to 12 years. Serum IgG1
and IgG2 concentrations were determined by enzyme linked
immunosorbent assay (ELISA) method.
Results: The mean serum IgG1 concentrations of children with DS in
both age groups did not differ significantly from that of normal healthy
children. But the IgG2 level was significantly less (p<0.003 and p<0.004)
in both age groups of children with DS compared to that of control healthy
Conclusion: The study has demonstrated that the serum IgG2 level was
significantly less in children with DS than that of matched normal healthy
control children while there was no deficiency of IgG1.
IMC J Med Sci 2017; 11(1): 1-4
for Correspondence: Dr.
Supti Prava Saha, Lecturer, Department of Pharmacology, Ibrahim Medical
College, 122 Kazi Nazrul Islam Avenue, Shahbag, Dhaka 1000, Bangladesh. Email: